Publications

 

2026

• Jesús Chaparro-García, Rafael Maldonado-Sánchez, Anaïck Moisan, Marga Blanco, Cristina Antúnez, Jorge Guerrero, Natividad Fernández, Marcela Eisman, Elena Tristante, Martínez-Lorenzo María José, Elena Vuelta, Javier Calvo, Purificación Catalina, Alicia Moreno Pantoja, Mónica Santos González, María Bermejo, Blanca Arribas-Arribas, Laura Leyva, Antonio Rodríguez-Acosta Development of a proficiency testing platform for advanced therapies medicinal products (atmps) Cytotherapy, 2026, 24 February.doi.org/10.1016/j.jcyt.2026.102122

 

2025

• Eduardo Agüera-Morales, Victoria Eugenia Fernández-Sánchez, Guillermo Navarro-Mascarell, Juan Antonio Cabezas-Rodríguez, María Ángeles Peña-Toledo, Virginia Reyes-Rodríguez, María José Postigo-Pozo, Giorgio Patrignani-Ochoa, María Ángeles Geniz-Clavijo, Celedonio Márquez-Infante, Luis Tallon-Aguilar, José Tinoco-González, Javier Padillo-Ruiz, Amador Valladares-Sánchez, Candela Caballero-Eraso, Cecilia López-Ramírez, Rosario Mata Alcázar-Caballero, Laura Leyva-Fernández, Antonio Rodríguez-Acosta, Rafael Maldonado-Sánchez, María Luisa García-Martín, Mª Luisa Somoza-Ramírez, Blanca Quijano-Ruiz, María del Mar Macías-Sánchez, Gloria Carmona-Sánchez, Olga Fernández-López and Óscar Fernández-Fernández Adipose-derived mesenchymal stem cells for the treatment of Amyotrophic Lateral Sclerosis. A phase I/II safety and efficacy clinical trial Frontiers in Neurology, 2025, 8 October.doi.org/10.3389/fneur.2025.1655124

• Víctor J. Costela-Ruiz, Encarnación González-Vigil, Olga Espinosa-Ibáñez, Rosario Mata Alcázar–Caballero, Lucía Melguizo-Rodríguez, Olga Fernández-López, Salvador Arias-Santiago Application of allogeneic adult mesenchymal stem cells in the treatment of venous ulcers: A phase I/II randomized controlled trial protocol PLOS One May 15, 2025.doi.org/10.1371/journal.pone.0323173.

• Celine Auxenfans, Rocio G. Valencia, Philippe Abdel-Sayed, Miguel Alaminos, Jean-François Brunet, Fernando Campos, Jesus Chato-Astrain, Gloria Carmona, Anthony de Buys Roessingh, Stephanie Droz-Georget, Melinda Farkas, Ana Fernandez Gonzalez, Enikö Gönczi,Fredrik Huss,Bernd Hartmann,Barbara Heusi,Alexandra Karström, Naiem Moiemen, Giulia Sartoris Laboratory-Generated Autologous Skin Substitutes for Burn Treatment in Europe: Narrative Review, Experts’ Opinion, and Legal ConsiderationsEur. Burn J. 2025, 6(2), 30. doi.org/10.3390/ebj6020030.

• Rocio García de la Cruz Valencia, Gloria Carmona Sánchez, Céline Auxenfans, Jean-François Brunet, Ana Fernández González, Vivienne Woodtli, Alexandra Karström & Marina Trouillas Quality Controls of Autologous Skin Products According to European GMP Guidelines Methods in Molecular Biology ((MIMB,volume 2922)) 11 April 2025. doi.org/10.1007/978-1-0716-4510-9_25.

• Elena Maryamchik, Ashley Krull, Yvette C. Tanhehco, Medhat Askar, Cheryl Cox, Wanxing Cui, Maggie DiGuardo, Fajar Dumadi, Jelena L. Holovati, Diane Kadidlo, Sufira Kiran, Raymond Lam, Nadim Mahmud, Gloria Carmona Sanchez, Joseph (Yossi) Schwartz Shaping the Future of Cell and Gene Therapy Workforce Development: Training of Cell Therapy Processing Personnel Cytotherapy. April 09, 2025.doi.org/10.1016/j.jcyt.2025.04.060.

• Antonio España-López, Ricardo Fernández-Valadés, Elisa Cubiles, Ingrid Garzón, Miguel Angel Martin-Piedra, Víctor Carriel, Fernando Campos, Adoración Martínez-Plaza, Daniel Vallejo, Esther Liceras-Liceras, Jesús Chato-Astrain, Oscar Dario García-García, David Sánchez-Porras, Paula Ávila-Fernández, Miguel Etayo-Escanilla, Blanca Quijano, Elisabet Aguilar, Antonio Campos, Gloria Carmona, Miguel Alaminos A phase I-IIa clinical trial to evaluate the safety, feasibility, and efficacy of the use of a palate mucosa generated by tissue engineering for the treatment of children with cleft palate: the BIOCLEFT study protocol BMJ Open. 2025 Jan. 14(12).doi.org/10.1136/bmjopen-2024-093491.

 

2024

• Carlos Casado, Carmen Cepeda-Franco, Sheila Pereira Arenas, Maria Dolores Suarez, Miguel Ángel Gómez-Bravo, Miguel Alaminos, Jesús Chato-Astrain, Beatriz Fernández-Muñoz & Rafael Campos-Cuerva. Cryopreserved nanostructured fibrin-agarose hydrogels are efficient and safe hemostatic agents Scientific Reports. 2024 Aug. 21;14(1):19411.doi.org/10.1038/s41598-024-70456-w.

• Belén Sierro-Martínez, Virginia Escamilla-Gómez, Laura Pérez-Ortega, Beatriz Guijarro-Albaladejo, Paola Hernández-Díaz · María de la Rosa-Garrido, Maribel Lara-Chica, Alfonso Rodríguez-Gil, Juan Luis Reguera-Ortega, Luzalba Sanoja-Flores, Blanca Arribas-Arribas, Miguel Ángel Montiel-Aguilera, Gloria Carmona, Maria Jose Robles, Teresa Caballero-Velázquez, Javier Briones, Hermann Einsele, Michael Hudecek, Jose Antonio Pérez-Simón, Estefanía García-Guerrero. Next-Generation BCMA-targeted Chimeric Antigen Receptor CARTemis-1: The Impact of Manufacturing Procedure on CAR T-Cell Features. Cellular Oncology. 2024 Aug .doi.org/10.1007/s13402-024-00984-0.

• Ana Ubago-Rodríguez, María I Quiñones-Vico, Manuel Sánchez-Díaz, Raquel Sanabria-de la Torre, Álvaro Sierra-Sánchez, Trinidad Montero-Vílchez, Ana Fernández-González, Salvador Arias-Santiago. Challenges in Psoriasis Research: A Systematic Review of Preclinical Models. Dermatology. Dermatology (2024) June 240 (4): 620–652 .doi.org/10.1159/000538993.

• María I. Quiñones-Vico , Ana Fernández-González, Ana Ubago-Rodríguez, Kirsten Moll, Anna Norrby-Teglund, Mattias Svensson, José Gutiérrez-Fernández, Jesús M. Torres; Antibiotics against Pseudomonas aeruginosa on Human Skin Cell Lines: Determination of the highest non-cytotoxic concentrations with antibiofilm capacity for wound healing strategies Pharmaceutics. 2024 Jan 17;16(1):117.doi.org/10.3390/pharmaceutics16010117.

2023

 

• • Blanca Arribas-Arribas, Beatriz Fernández-Muñoz, Rafael Campos-Cuerva, Miguel Ángel Montiel-Aguilera, María Bermejo-González, Isabel Lomas-Romero, María Martín-López, Rosario Mata Alcázar-Caballero, María del Mar Macías-Sánchez, Fernando Campos, Miguel Alaminos, Tomás Gómez-Cía, Purificación Gacto, Gloria Carmona, Mónica Santos-González; Nanostructured fibrin-agarose hydrogels loaded with allogeneic fibroblasts as bio-dressings for acute treatment of massive burns Biomedicine & Pharmacotherapy. Volume 168, December 2023.doi.org/10.1016/j.biopha.2023.115769.

• • Belén Sierro-Martínez, Virginia Escamilla Gómez, Laura Perez Ortega, Beatriz Guijarro Albaladejo, Paola Hernández Díaz, María de la Rosa Garrido, Maribel Lara-Chica, Juan Luis Reguera, Luzalba Sanoja Flores, Blanca Arribas-Arribas, Miguel-Ángel Montiel Aguilera, Gloria Carmona, Maria Jose Robles, Teresa Caballero, Javier Briones, Hermann Einsele, Michael Hudecek, Jose A. Pérez Simón, Estefanía García Guerrero; New Optimized Academic Anti-BCMA CAR (CARTemis-1): How Does the Manufacturing Process Impact CAR-T Cell Features? Blood (2023) 142 (Supplement 1): 6866. November 2023.doi.org/10.1182/blood-2023-186095.

• • Álvaro Sierra-Sánchez, Brice Magne, Etienne Savard, Christian Martel, Karel Ferland, Martin A Barbier, Anabelle Demers, Danielle Larouche, Salvador Arias-Santiago, Lucie Germain In vitro comparison of human plasma-based and self-assembled tissue-engineered skin substitutes: two different manufacturing processes for the treatment of deep and difficult to heal injuries Burns Trauma. 2023 Oct 30:11:tkad043.doi.org/10.1093/burnst/tkad043.

• • Alessia Cavazza, Ayal Hendel, RasmusO. Bak, Paula Rio, Marc Güell, Duško Lainšček, Virginia Arechavala-Gomeza, Ling Peng, Fatma Zehra Hapil, Joshua Harvey, Francisco G. Ortega, Coral Gonzalez-Martinez, Carsten W. Lederer, Kasper Mikkelsen, Giedrius Gasiunas, Nechama Kalter, Manuel A.F.V. Gonçalves, Julie Petersen, Alejandro Garanto, Lluis Montoliu, Marcello Maresca, Stefan E. Seemann, Jan Gorodkin, Loubna Mazini, Rosario Sanchez, Juan R. Rodriguez-Madoz, Noelia Maldonado-Pérez, Torella Laura, Michael Schmueck-Henneresse, Cristina Maccalli, Julian Grünewald, Gloria Carmona, Neli Kachamakova-Trojanowska, Annarita Miccio, Francisco Martin, Giandomenico Turchiano, Toni Cathomen, Yonglun Luo, Shengdar Q. Tsai, Karim Benabdellah Progress and Harmonization of Gene Editing to Treat Human Diseases (Proceeding of COST Action CA21113 GenE-HumDi) Molecular Therapy – Nucleic Acids. 29 October 2023.doi.org/10.1016/j.omtn.2023.102066.

• • Álvaro Sierra-Sánchez, Martin A Barbier, Brice Magne, Danielle Larouche, Salvador Arias-Santiago, Lucie Germain Comparison of Two Human Skin Cell Isolation Protocols and Their Influence on Keratinocyte and Fibroblast Culture Int J Mol Sci. 2023 Sep 28;24(19):14712.doi.org/10.3390/ijms241914712.

• • Emilio Gómez González, Olga Muñoz, Juan Carlos Gómez Martín, Jesús Aceituno Castro, Beatriz Fernández Muñoz, Jose Manuel Navas García, Alejandro Barriga Rivera, Isabel Fernández Lizaranzu, Francisco Javier Muñoz González, Rubén Parrilla Giráldez, Desiree Requena Lancharro, Pedro Gil Gamboa, José Luis Ramos, Cristina Rosell Valle, Carmen Gómez González , María Martín López, María Isabel Relimpio López, Manuel A. Perales Esteve, Antonio Puppo Moreno, Francisco José García Cózar, Lucía Olvera Collantes, Silvia de los Santos Trigo, Emilia Gómez, Rosario Sánchez-Pernaute, Javier Padillo Ruiz, Javier Márquez Rivas; Polarimetric imaging for the detection of synthetic models of SARS-CoV-2: A proof of concept Journal of Quantitative Spectroscopy and Radiative Transfer, Volume 302, July 2023, 108567.doi.org/10.1016/j.jqsrt.2023.108567.

• • Miguel Angel Martin-Piedra, Gloria Carmona, Fernando Campos, Víctor Carriel, Ana Fernández-González, Antonio Campos, Natividad Cuende, Ingrid Garzón, Purificación Gacto, Miguel Alaminos Histological assessment of nanostructured fibrin-agarose skin substitutes grafted in burnt patients. A time-course study Bioeng Transl Med. 2023 Jul 7;8(6):e10572.doi.org/10.1002/btm2.10572.

• • A. Rodriguez, J. Chaparro García, R. Maldonado, R. Muñoz, L. Iglesias, L. Leyva An in-house developed external assurance programme for advanced therapies, the first academic programme in Europe Cytotherapy volume 25, issue 6, supplement , s164, may 2023.doi.org/10.1016/S1465-3249(23)00441-3.

• • S. Estévez-Sánchez, L. Cruz-Hernández, B. Quijano-Ruiz, R. Mata,E. Aguilar-Bohorquez, G. Carmona The AND&TAT: a prosperous network in advanced therapies, their manufacture, clinical and preclinical use Cytotherapy volume 25, issue 6, supplement , s156, may 2023.doi.org/10.1016/S1465-3249(23)00425-5.

• • R. Campos, C. Antunez, R. Sanchez Pernaute, M. S. Gonzalez Transcriptomic analysis of human mesenchymal stem cells from umbilical cord expanded with inactivated gmp-grade human platelet lysate Cytotherapy volume 25, issue 6, supplement , s57, may 2023. doi.org/10.1016/S1465-3249(23)00223-2.

• • J. Chaparro García, A. Rodríguez, R. Maldonado, M. Codinach; A practical risk-based approach for the manufacturing of mesenchymal stromal cells-derived medicinal products in the allogeneic setting Cytotherapy. Volume 25, Issue 6, Suplement, S44, May 2023.doi.org/10.1016/S1465-3249(23)00199-8.

• • F. Moniche, B. Quijano-Ruiz, R. Valverde, M. Gamero, R. Espinosa, M. Macías, O. Fernandez, G. Carmona, R. Mata; Treatment of acute ichemic stroke with bone marrow mononuclear cells. A phase IIB randomized, dose-finding, single-blind controlled multicenter trial Cytotherapy. Volume 5, Issue 6, Suplement, S16, May 2023.doi.org/10.1016/S1465-3249(23)00153 6.

• • A.B. Garcia-Delgado, R. Campos, M. Suarez-Pizarro, C. Casado, C.R. del Valle, M. Martin-Lopez, L. Cruz-Hernandez, J. Marquez-Rivas, R. Sanchez-Pernaute et B. Fernández Muñoz Ipsc: using organoids to evaluate the safety and efficacy profile of cell therapeutics Cytotherapy, 2023-05-01, Volume 25, Numéro 6, Pages S277-S277.doi.org/10.1016/S1465-3249(23)00681-3.

• • María Martín López, Cristina Rosell Valle, Blanca Arribas Arribas, Beatriz Fernández Muñoz, Rosario Jiménez, Sonia Nogueras, Ana Belén García Delgado, Fernando Campos, Mónica Santos González. Bioengineered tissue and cell therapy products are efficiently cryopreserved with pathogen-inactivated human platelet lysate-based solutions. Stem Cell Res Ther. 2023 Apr 7;14(1):69. doi.org/10.1186/s13287-023-03300-z.

• • Carmen González-Gallardo, Juliana Martínez-Atienza, Beatriz Mataix, José Ignacio Muñoz-Ávila, J Daniel Martínez-Rodríguez, Santiago Medialdea, Antonio Ruiz-García, Antonio Lizana-Moreno, Salvador Arias-Santiago, Manuel de la Rosa-Fraile, Ingrid Garzon, Antonio Campos, Natividad Cuende, Miguel Alaminos, Miguel González-Andrades, Rosario Mata. Successful restoration of corneal surface integrity with a tissue-engineered allogeneic implant in severe keratitis patients. Biomed Pharmacother. 2023 Jun;162:114612. doi.org/10.1016/j.biopha.2023.114612.

• • Fermín Sánchez-Guijo, Cristina Avendaño-Solá, Lina Badimón, Juan Bueren, Josep M Canals, Joaquin Delgadillo Duarte, Julio Delgado, Cristina Eguizábal, María-Eugenia Fernández-Santos, Damián García-Olmo, Gloria González-Aseguinolaza, Manel Juan, Francisco Martín, Rosario Mata, Nuria Monserrat, Antonio Perez-Martinez, José A Pérez-Simón, Felipe Prosper, Alvaro Urbano-Ispizua, Agustín G Zapata, Anna Sureda & Jose Moraleda. Role of Hospital Exemption in Europe: position paper from the Spanish Advanced Therapy Network (TERAV). Bone Marrow Transplant. 2023 Mar 25. doi.org/10.1038/s41409-023-01962-0.

• • Francisco Moniche, Juan Antonio Cabezas-Rodriguez, Roberto Valverde, Irene Escudero-Martinez, Lucia Lebrato-Hernandez, Blanca Pardo-Galiana, Leire Ainz, Manuel Medina-Rodriguez, Javier de la Torre, Virginia Escamilla-Gomez, Joaquin Ortega-Quintanilla, Elena Zapata-Arriaza, Asier de Albóniga-Chindurza, Fernando Mancha, Miguel-Angel Gamero, Soledad Perez, Raul Espinosa-Rosso, Lucia Forero-Diaz, Miguel Moya, Pilar Piñero, Cristina Calderón-Cabrera, Sonia Nogueras, Rosario Jimenez, Vanesa Martin, Fernando Delgado, Juan-José Ochoa-Sepúlveda, Blanca Quijano, Rosario Mata, Monica Santos-González, Gloria Carmona-Sanchez, Concha Herrera, Alejandro Gonzalez,Joan Montaner. Safety and efficacy of intra-arterial bone marrow mononuclear cell transplantation in patients with acute ischaemic stroke in Spain (IBIS trial): a phase 2, randomised, open-label, standard-of-care controlled, multicentre trial. Lancet Neurol. 2023 Feb;22(2):137-146. doi.org/10.1016/S1474-4422(22)00526-9

• • Garcia-Calderon CB; Sierro-Martinez B; García-Guerrero E; Sanoja-Flores L; Muñoz-Garcıa R; Ruiz-Maldonado V; Jimenez-Leon MR; Delgado-Serrano J; Molinos-Quintana A; Guijarro-Albaladejo B; Carrasco-Brocal I; Lucena J-M; Garcıa-Lozano JR; Blzquez-Goñi C; Reguera-Ortega JL; Gonzalez-Escribano MF; Reinoso-Segura M; Briones J; Perez-Simon JA; Caballero-Velazquez T. Monitoring of kinetics and exhaustion markers of circulating CAR-T cells as early predictive factors in patients with B-cell malignancies. doi.org/ 10.3389/fimmu.2023.1152498.

2022

• • Murueta-Goyena A, Cipriani R, Carmona-Abellán M, Acera M, Ayo N, Del Pino R, Tijero B, Fernández-Valle T, Gabilondo I, Zallo F, Matute C, Sánchez-Pernaute R, Khurana V, Cavaliere F, Capetillo-Zarate E, Gómez-Esteban JC. Characterization of molecular biomarkers in cerebrospinal fluid and serum of E46K-SNCA mutation carriers. Parkinsonism Relat Disord. 2022 Mar;96:29 35.doi.org/10.1016/j.parkreldis.2022.01.024

• • Ana Belén García-Delgado. Rafael Campos-Cuerva. Cristina Rosell-Valle. María Martin-López. Carlos Casado. Daniela Ferrari. Javier Márquez-Rivas. Rosario Sánchez-Pernaute. Beatriz Fernández-Muñoz. Brain Organoids to Evaluate Cellular Therapies. Animals (Basel). 2022 Nov 15;12(22):3150. doi.org/10.3390/ani12223150

• • Tristan-Manzano, M; Maldonado-Perez, N ; Justicia-Lirio, P ; Munoz, P; Cortijo-Gutierrez, M; Pavlovic, K; Jimenez-Moreno, R; Nogueras, S; Carmona, MD; Sanchez-Hernandez, S; Aguilar-Gonzalez, A; Castella, M; Juan, M; Maranon, C; Marchal, JA; Benabdellah, K; Herrera, C; Martin, F. Physiological lentiviral vectors for the generation of improved CAR-T cells. Mol Ther Oncolytics. 2022 May 18;25:335-349. doi.org/10.1016/j.omto.2022.05.003

• • Costela Ruiz VJ, Melguizo Rodríguez L, Illescas Montes R, García Recio E, Arias Santiago S, Ruiz C, De Luna Bertos E.  Human adipose tissue-derived mesenchymal stromal cells and their phagocytic capacity. J Cell Mol Med. 2022 Jan;26(1):178-185. doi.org/10.1111/jcmm.17070

• • García-Valdivia M, Quiñones-Vico MI, Ortega-Llamas L, Fernández-González A, Ubago-Rodríguez A, Sanabria-de la Torre R, Arias-Santiago S. Cytotoxicity, Epidermal Barrier Function and Cytokine Evaluation after Antiseptic Treatment in Bioengineered Autologous Skin Substitute. Biomedicines. 2022 Jun 19;10(6):1453. doi.org/10.3390/biomedicines10061453

• • Rosell-Valle, Cristina, María Martín-López, Fernando Campos, Jesús Chato-Astrain, Rafael Campos-Cuerva, Miguel Alaminos, Mónica Santos González.  Inactivation of human plasma alters the structure and biomechanical properties of engineered tissues. Front Bioeng Biotechnol. 2022 Aug 23;10:908250. doi.org/10.3389/fbioe.2022.908250

• • Rodríguez Calvo-de-Mora M, Domínguez-Ruiz C, Barrero-Sojo F, Rodríguez-Moreno G, Antúnez Rodríguez C, Ponce Verdugo L, Hernández Lamas MDC, Hernández-Guijarro L, Villalvilla Castillo J, Fernández-Baca Casares I, Prat Arrojo I, Borroni D, Alba-Linero C, Zamorano-Martín F, Moreno-Guerrero A, Rocha-de-Lossada C. Autologous versus allogeneic versus umbilical cord sera for the treatment of severe dry eye disease: a double-blind randomized clinical trial. Acta Ophthalmol. 2022 Mar;100(2):e396-e408. doi.org/10.1111/aos.14953

• • Gevers-Montoro C, Romero-Santiago M, Losapio L, Conesa-Buendía FM, Newell D, Álvarez-Galovich L, Piché M, Ortega-De Mues. A  Presence of Tumor Necrosis Factor-Alpha in Urine Samples of Patients With Chronic Low Back Pain Undergoing Chiropractic Care: Preliminary Findings From a Prospective Cohort Study. Front Integr Neurosci. 2022 Apr 12;16:879083. doi.org/10.3389/fnint.2022.879083

• • Gevers-Montoro C, Deldar Z, Conesa-Buendía FM, Lazar EA, Mahillo-Fernandez I, Khatibi A, Ortega de Mues A. Pain catastrophizing mediates rapid benefits of accessing in-person chiropractic care during the COVID-19 lockdown. Eur J Pain. 2022 Feb;26(2):463-479. doi.org/10.1002/ejp.1872

• • Garikoitz Azkona, Rosario Sánchez-Pernaute. Mice in translational neuroscience: What R we doing? Prog Neurobiol. 2022 Oct; 217:102330. doi.org/10.1016/j.pneurobio.2022.102330

• • Antonio Olry de Labry-Lima, Angela Ponce-Polo, Leticia García-Mochón, Marta Ortega-Ortega, Daniel Pérez-Troncoso, David Epstein. Challenges for Economic Evaluations of Advanced Therapy Medicinal Products: A Systematic Review. Aug 25; S1098-3015(22)02100-3. doi.org/10.1016/j.jval.2022.07.004

• • María Bermejo González. Rafael Campos Cuerva. Beatriz Fernández Muñoz. Cristina Rosell-Valle. María Martín López. Blanca Arribas Arribas. Miguel Ángel Montiel. Gloria Carmona Sánchez. Mónica Santos. Optimization of human platelet lysate production and pathogen reduction in a public blood transfusion center. 2022 August 4. doi.org/10.1111/trf.17045

• • Luis Lopez-Navas, Silvia Torrents, Rosario Sánchez-Pernaute, Joaquim Vives. Compliance in Non-Clinical Development of Cell-, Gene-, and Tissue-Based Medicines: Good Practice for Better Therapies. 2022 July 13. doi.org/10.1093/stcltm/szac046

• • Laura Ortega-Llamas, María I. Quiñones-Vico, Marta García-Valdivia, Ana Fernández-González, Ana Ubago-Rodríguez, Raquel Sanabria-de la Torre and Salvador Arias-Santiago. Cytotoxicity and Wound Closure Evaluation in Skin Cell Lines after Treatment with Common Antiseptics for Clinical Use. 2022 Apr 20;11(9):1395.  doi: 10.3390/cells11091395

• • Montero-Vilchez T. Martinez-Lopez A. Cuenca-Barrales C. I Quiñones-Vico M. Sierra-Sanchez A. Molina-Leyva A. Gonçalo M. Cambil-Martin J. Arias-Santiago S. Assessment of hand hygiene strategies on skin barrier function during COVID-19 pandemic: A randomized clinical trial. 2022 Apr;86(4):276-285. doi: 10.1111/cod.14034

• • Macías-Sánchez MdM, Morata-Tarifa C, Cuende N, Cardesa-Gil A, Cuesta-Casas MÁ, Pascual-Cascon MJ, Pascual A, Martín-Calvo C, Jurado M, Perez-Simón JA, Espigado I, Garzón López S, Carmona Sánchez G, Mata-Alcázar-Caballero R, Sánchez-Pernaute R. Mesenchymal Stromal Cells for Treating Steroid-Resistant Acute and Chronic Graft Versus Host Disease: A Multicenter Compassionate Use Experience.2022 Apr 29;11(4):343-355.  doi: 10.1093/stcltm/szac003

• • Ponce Polo Á, Ritoré Hidalgo A, Argüello Martínez A, Oruezabal Guijarro RI. Use of patent information to characterize trends in the therapeutic applications of extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) 2022 Mar 3.  doi:10.2174/1872208316666220303095217

• • Murueta-Goyena A, Cipriani R, Carmona-Abellán M, Acera M, Ayo N, Del Pino R, Tijero B, Fernández-Valle T, Gabilondo I, Zallo F, Matute C, Sánchez-Pernaute R, Khurana V, Cavaliere F, Capetillo-Zarate E, Gómez-Esteban JC. Characterization of molecular biomarkers in cerebrospinal fluid and serum of E46K-SNCA mutation carriers. 2022 Mar; 96:29-35. doi:10.1016/j.parkreldis.2022.01.024

• • García-Guerrero E; Rodríguez-Lobato LG; Sierro-Martínez B; Danhof S; Bates S; Frenz S; Haertle L; Götz R; Sauer M; Rasche L; Kortüm KM; Pérez-Simón JA; Einsele H; Hudecek M; Prommersberger SR. All-trans retinoic acid works synergistically with the γ-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T cells. Haematologica. 2023 Feb 1;108(2):568-580. doi.org/10.3324/haematol.2022.281339

• • Rodríguez-Acosta A, Chaparro-García J, De-Toro I, Maldonado-Sanchez R, Muñoz-Fernández R, Antúnez C, Frecha C, Leyva L. Technical challenges for complete implementation of automated growth based methods for microbiological examination of advanced therapy medicinal products. What’s wrong with Candida albicans?. 2022.Mar; 24(3):320-333. doi:10.1016/j.jcyt.2021.11.002

• • Rodriguez Gil Alfonso, Escamilla Gomez Virginia, Nufer Melanie, Andujar Sanchez Felix, Lopes Ramos Teresa, Bejarano Garcia Jose Antonio, Garcia Guerrero Estefania, Calderon Cabrera Cristina, Caballero Velazquez Teresa, Garcia Calderon Clara Beatriz, Hernandez Diaz Paola, Reguera Ortega Juan Luis, Rodriguez Torres Nancy, Martinez Cibrian Nuria, Rodriguez Barbosa Jose Ignacio, Villadiego Javier, Perez Simon Jose Antonio. Combined treatment of graft versus host disease using donor regulatory T cells and ruxolitinib. Sci Rep. 2022 May 19;12(1):8348. doi.org/10.1038/s41598-022-12407-x

• • Gomez-Gonzalez E, Barriga-Rivera A, Fernandez-Muñoz B, Navas-Garcia JM, Fernandez-Lizaranzu I, Munoz-Gonzalez FJ, Parrilla-Giraldez R, Requena-Lancharro D, Gil-Gamboa P, Rosell-Valle C, Gomez-Gonzalez C, Mayorga-Buiza MJ, Martin-Lopez M, Muñoz O, Gomez-Martin JC, Relimpio-Lopez MI, Aceituno-Castro J, A Perales-Esteve M, Puppo-Moreno A, Garcia-Cozar FJ, Olvera-Collantes L, Gomez-Diaz R, De Los Santos-Trigo S, Huguet-Carrasco M, Rey M, Gomez E, Sanchez-Pernaute R, Padillo-Ruiz J, Marquez-Rivas J. Optical imaging spectroscopy for rapid, primary screening of SARS-CoV-2: a proof of concept. 2022 Feb 18;12(1):2356. doi: 10.1038/s41598-022-06393-3

• • Fernández Muñoz B, López Navas L , Bermejo Gonzalez M, Lomas Romero I, Montiel M, Campos Cuerva R, Arribas Arribas B, Nogueras S, Carmona Sánchez G, Santos González M. A proprietary GMP human platelet lysate for the expansion of dermal fibroblasts for clinical applications.2022 Jan 2;33(1):98-109. https://doi.org/ 10.1080/09537104.2020.1856356

2021

• • Martin-Lopez M. Gonzalez-Muñoz E. Gomez Gonzalez E. Sanchez-Pernaute R. Marquez Rivas J. Fernandez-Muñoz B. Modeling Chronic Cervical Spinal Cord Injury in Aged Rats for Cell Therapy Studies. 2021 Dec; 94:76-85. doi: 10.1016/j.jocn.2021.09.042

• • Martin-Lopez M., Fernandez-Muñoz B., Canovas S. Pluripotent Stem Cells for Spinal Cord Injury Repair. 2021 Nov.27. https://doi.org/10.3390/cells10123334

• • Atencio P, Cabello A, Conesa-Buendía FM, Pérez-Tanoira R, Prieto-Pérez L, Carrillo I, Álvarez B, Arboiro-Pinel R, Díaz-Curiel M, Herrero-Beaumont G, Mediero A, Górgolas M. Increased risk factors associated with lower BMD in antiretroviral-therapy-naïve HIV-infected adult male. BMC Infect Dis. 2021 Jun 9;21(1):542. doi.org/10.1186/s12879-021-06263-9

• • Atencio P, Conesa-Buendía FM, Cabello-Ubeda A, Llamas-Granda P, Pérez-Tanoira R, Prieto-Pérez L, Álvarez BÁ, Acosta IC, Arboiro-Pinel R, Díaz-Curiel M, Largo R, Herrero-Beaumont G, Górgolas M, Mediero A.  Bone Deleterious Effects of Different NRTIs in Treatment-naïve HIV Patients After 12 and 48 Weeks of Treatment. Curr HIV Res. 2021;19(5):434-447. doi.org/10.2174/1570162X19666210805094434

• • C Axfors. P Janiaud . A M Schmitt. J Van’t Hooft. E R Smith. No A Haber. A Abayomi. M Abduljalil. A Abdulrahman. Y Acosta-Ampudia. M Aguilar-Guisado. F Al-Beidh. M M Alejandria. R N Alfonso. M Ali. M AlQahtani. A AlZamrooni. J Anaya. M A C Ang. I F Aomar. L E Argumanis. A Averyanov. V P Baklaushev. O Balionis. T Benfield. S Berry. N Birocco. L B Bonifacio. A C Bowen. A Bown. C Cabello-Gutierrez. B Camacho. A Camacho-Ortiz. S Campbell-Lee. D H Cao. A Cardesa. J M Carnate. G Jr J Castillo. R Cavallo. F R Chowdhury. F U H Chowdhury. G Ciccone. A Cingolani. F M M Climacosa. V Compernolle. C F N Cortez. A Costa Neto. S D’Antico. J Daly. F Danielle. J S Davis. F G De Rosa. J T Denholm. C M Denkinger. D Desmecht. J C Díaz-Coronado. J A Díaz Ponce-Medrano. A-F Donneau. T E Dumagay. S Dunachie. C C Dungog. O Erinoso. I Mae S Escasa. L J Estcourt. A Evans. A L M Evasan. C J Fareli. V Fernandez-Sanchez. C Galassi. J E Gallo. P J Garcia. P L Garcia. J A Garcia. M Garigliany. E Garza-Gonzalez. D Thaddeus V Gauiran. P A Gaviria García. J- Giron-Gonzalez. D Gómez-Almaguer. A C Gordon. A Gothot. J S Grass Guaqueta. C Green. D Grimaldi. N E Hammond. H Harvala. F M Heralde. J Herrick. A M Higgins. T E Hills. J Hines. K Holm. A Hoque. E Hoste. J M Ignacio. A V Ivanov. M Janssen. J H Jennings. V Jha R A N King. J Kjeldsen-Kragh. P Klenerman. A Kotecha . F Krapp. L Labanca. E Laing. M Landin-Olsson. P-F Laterre. L-L Lim. J Lim. O Ljungquist. J M Llaca-Díaz. C López-Robles. S López-Cárdenas. I Lopez-Plaza. J A C Lucero. M Lundgren. J Macías. S C Maganito. A F G Malundo. R D Manrique. P M Manzini. M Marcos. I Marquez. F J Martínez-Marcos. A M Mata. C J McArthur. Z K McQuilten. B J McVerry. D K Menon. G Meyfroidt. M A L Mirasol. B Misset. J S Molton. A V Mondragon. D M Monsalve. P Moradi Choghakabodi. S C Morpeth. P R Mouncey. M Moutschen. C Müller-Tidow. E Murphy. T Najdovski. A D Nichol. H Nielsen. R M Novak. M V N O’Sullivan. J Olalla. A Osibogun. B Osikomaiya. S Oyonarte. J M Pardo-Oviedo. M C Patel. D L Paterson. C A Peña-Perez. A A Perez-Calatayud. E Pérez-Alba. A Perkina. N Perry. M Pouladzadeh. I Poyato. D J Price. A K H Quero. Md M Rahman. Md S Rahman. M Ramesh. C Ramírez-Santana. M Rasmussen. M A Rees. E Rego. J A Roberts. D J Roberts. Y Rodríguez. J Rodríguez-Baño. B A Rogers. M Rojas. A Romero. K M Rowan. F Saccona. M Safdarian. M C M Santos. J Sasadeusz. G Scozzari. M Shankar-Hari. G Sharma. T Snelling. A Soto. P Y Tagayuna. A Tang. G Tatem. L Teofili. S Y C Tong. A F Turgeon. J D Veloso. B Venkatesh. Y Ventura-Enriquez. S A Webb. L Wiese. Ch Wikén. E M Wood. G M Yusubalieva. K Zacharowski. R Zarychanski. N Khanna. D Moher. S N Goodman. J P A Ioannidis. L G Hemkens. Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials. 2021 Nov 20;21(1):1170. https://doi.org/10.1186/s12879-021-06829-7

• • Delgado-Fernández M, García-Gemar GM, Fuentes-López A, Muñoz-Pérez MI, Oyonarte-Gómez S, Ruíz-García I, Martín-Carmona J, Sanz-Cánovas J, Castaño-Carracedo MÁ, Reguera-Iglesias JM, Ruíz-Mesa JD. Treatment of COVID-19 with convalescent plasma in patients with humoral immunodeficiency – Three consecutive cases and review of the literature. Enferm Infecc Microbiol Clin (Engl Ed). 2022 Nov;40(9):507-516. doi.org/10.1016/j.eimce.2021.01.009

• • Fernandez-Muñoz, B.;Garcia-Delgado, A.B.;Arribas-Arribas, B.;Sanchez-Pernaute. Human Neural Stem Cells for Cell-Based Medicinal Products. Cells 2021 Sept.9, 10 (9),2377.https://doi.org/10.3390/cells10092377

• • Gomez-Gonzalez E, Fernandez-Muñoz B, Barriga-Rivera A, Navas-Garcia JM, Fernandez-Lizaranzu I, Munoz-Gonzalez FJ, Parrilla-Giraldez R, Requena-Lancharro D, Guerrero-Claro M, Gil-Gamboa P, Rosell-Valle C, Gomez-Gonzalez C, Mayorga-Buiza MJ, Martin-Lopez M, Muñoz O, Martin JCG, Lopez MIR, Aceituno-Castro J, Perales-Esteve MA, Puppo-Moreno A, Cozar FJG, Olvera-Collantes L, de Los Santos-Trigo S, Gomez E, Pernaute RS, Padillo-Ruiz J, Marquez-Rivas J. Hyperspectral image processing for the identification and quantification of lentiviral particles in fluid samples. Sci Rep. 2021 Aug 10;11(1):16201. doi: 10.1038/s41598-021-95756-3. PMID: 34376765; PMCID: PMC8355230.

• • Rosell-Valle C, Antunez C, Campos F, Gallot N, García-Arranz M, García-Olmo D, Gutierrez R , Hernan R , Herrera C, Jimenez R, Leyva-Fernandez L, Maldonado-Sanchez R, Munoz-Fernandez R, Noguera S , Ortiz L, Piudo I, Ranchall I, Rodríguez-Acosta A, Segovia C, Fernandez-Muñoz B. Evaluation of the effectiveness of a new cryopreservation system based on a two-compartment vial for the cryopreservation of cell therapy products.Cytotherapy. Volume 23, Issue 8, August 2021, Pages 740-753. https://doi.org/10.1016/j.jcyt.2020.12.004

• • Raquel Sanabria-de la Torre. María I. Quiñones-Vico. Ana Fernández-González. Manuel Sánchez-Díaz. Trinidad Montero-Vilchez. Álvaro Sierra-Sánchez. Salvador Arias-Santiago.  Alloreactive Immune Response Associated to Human Mesenchymal Stromal Cells Treatment: A Systematic Review. 2021 Jul 5;10(13):2991. https://doi.org/ 10.3390/jcm10132991

• • Ortiz-Arrabal O. Carmona R. García-García O. Chato-Astrain J. Sánchez-Porras D. Domezain A. Oruezabal R. Carriel V. Campos A. Alaminos M. Generation and Evaluation of Novel Biomaterials Based on Decellularized Sturgeon Cartilage for Use in Tissue Engineering. 2021 July 4, 9(7), 775. https://doi.org/10.3390/biomedicines9070775

• • Manuel Sanchez-Diaz, Maria I. Quiñones-Vico, Raquel Sanabria de la Torre, Trinidad Montero-Vílchez, Alvaro Sierra-Sanchez, Alejandro Molina-Leyva, Salvador Arias-Santiago. Biodistribution of Mesenchymal Stromal Cells afterAdministration in Animal Models and Humans:A Systematic Review. 2021 Jun 29;10(13):2925. https://doi.org/10.3390/jcm10132925

• • Trujillo-Rodríguez M, Viciana P, Rivas-Jeremías I, Álvarez-Ríos A, Ruiz-García A, Espinosa-Ibáñez O, Arias-Santiago S, Martínez-Atienza J, Mata R, Fernández-López O, Ruiz-Mateos E, Gutiérrez-Valencia A, López-Cortés L. Mesenchymal stromal cells in human immunodeficiency virus-infected patients with discordant immune response: Early results of a phase I/II clinical trial. Stem Cells Translational Medicine. 2021 Apr;10(4):534-541. https://doi.org/10.1002/sctm.20-0213

• • Morata-Tarifa C, Azkona G, Glass J, Mazzini L, Sanchez-Pernaute R. Looking backward to move forward: a meta-analysis of stem cell therapy in amyotrophic lateral sclerosis. NPJ Regen Med. 2021 Apr 1;6(1):20. https://doi.org/10.1038/s41536-021-00131-5.

2020

• • Conesa-Buendía FM, Mediero A, Fujikawa R, Esbrit P, Mulero F, Mahillo-Fernández I, Mues AO.  Beneficial effects of manually assisted chiropractic adjusting instrument in a rabbit model of osteoarthritis. Sci Rep. 2020 Aug 6;10(1):13237. doi.org/10.1038/s41598-020-70219-3

• • Conesa-Buendía FM, Llamas-Granda P, Atencio P, Cabello A, Górgolas M, Largo R, Herrero-Beaumont G, Mediero A.  Adenosine Deaminase as a Biomarker of Tenofovir Mediated Inflammation in Naïve HIV Patients. Int J Mol Sci. 2020 May 19;21(10):3590. doi.org/10.3390/ijms21103590

• • Fernando de la Portilla, José Luis Guerrero, Maria Victoria Maestre, Laura Leyva, Santiago Mera, Damián García-Olmo, Antonio Rodríguez, Rosario Mata, Fabiola Lora. Treatment of faecal incontinence with autologous expanded mesenchymal stem cells: results of a pilot study. 2021 Mar;23(3):698-709. https://doi.org/10.1111/codi.15382

• • Chato-Astrain J, Chato-Astrain I, Sánchez-Porras D, García-García O, Bermejo-Casares F, Vairo C, Villar-Vidal M, Gainza G, Villullas S, Oruezabal R, Ponce-Polo A, Garzón I, Carriel V, Campos F, Alaminos M. Generation of a novel human dermal substitute functionalized with antibiotic-loaded nanostructured lipid carriers (NLCs) with antimicrobial properties for tissue engineering. Journal of Nanobiotechnology 18. Article number: 174 (2020). 23 noviembre 2020. https://doi.org/10.1186/s12951-020-00732-0

• • Aguilar Elisabet. Cell & Gene Therapy Insights 2020; 6(8), 1135–1140  The supply chain: key considerations for biological starting material for ATMPs production. 2020 September 22. https://10.18609/cgti.2020.123

• • Fernández-Muñoz B, Rosell-Valle C, Ferrari D, Alba-Amador J, Montiel MA, Campos-Cuerva R, Lopez-Navas L, Muñoz-Escalona M, Martín-López M, Profico DC, Blanco MF, Giorgetti A, González-Muñoz E, Márquez-Rivas J, Sanchez-Pernaute, R. Retrieval of germinal zone neural stem cells from the cerebrospinal fluid of premature infants with intraventricular haemorrhage. Stem Cells Translational Medicine, Volume 9, Issue 9, September 2020, Pages 1085–1101. https://doi.org/10.1002/sctm.19-0323

• • Maria Jose Ruiz Magaña, Jose Maria Puerta, Rocio Martínez-Aguilar, Tatiana Llorca, Osmany Blanco, Raquel Muñoz-Fernandez, Enrique G Olivares,Carmen Ruiz-Ruiz. Endometrial and decidual stromal precursors show a different decidualization capacity. 2020 Jul;160(1):83-91. https://doi.org/10.1530/REP-19-0465

• • Morata Tarifa C, López Navas L, Azkona G, Sánchez Pernaute R. Chimeras for the twenty-first century. Crit Rev Biotechnol. 2020 May;40(3):283-291. https//doi.org/10.1080/07388551.2019.1679084.

• • Morata-Tarifa C, Macías-Sánchez MM, Gutiérrez-Pizarraya A, Sanchez-Pernaute R. Mesenchymal stromal cells for the prophylaxis and treatment of graft-versus-host disease – A meta-analysis. Stem Cell Research and Therapy. 2020 Feb 18.11(1):64. https://doi.org/10.1186/s13287-020-01592-z

• • Grinan-Lison C, Olivares-Urbano MA, Jimenez G, Lopez-Ruiz E, Del Val C, Morata-Tarifa C, Entrena JM, Gonzalez-Ramirez AR, Boulaiz H, Zurita Herrera M, Nunez MI, Marchal JA. miRNAs as radio-response biomarkers for breast cancer stem cells. Molecular Oncology.13 January 2020. https://doi.org/10.1002/1878-0261.12635

• • Raquel Tarazona, Nelson Lopez-Sejas, Beatriz Guerrero, Fakhri Hassouneh, Isabel Valhondo, Alejandra Pera , Beatriz Sanchez-Correa, Nieves Pastor, Esther Duran, Corona Alonso, Rafael Solana. Current progress in NK cell biology and NK cell-based cancer immunotherapy. Cancer Immunol Immunother. 2020 May;69(5):879-899. doi.org/ 10.1007/s00262-020-02532-9

• • Isabel Valhondo, Fakhri Hassouneh, Nelson Lopez-Sejas, Alejandra Pera, Beatriz Sanchez-Correa, Beatriz Guerrero, Juan M Bergua, Maria Jose Arcos, Helena Bañas Ignacio Casas-Avilés, Joaquin Sanchez-Garcia, Josefina Serrano, Carmen Martin, Esther Duran, Corona Alonso, Rafael Solana, Raquel Tarazona.  Characterization of the DNAM-1, TIGIT and TACTILE Axis on Circulating NK, NKT-Like and T Cell Subsets in Patients with Acute Myeloid Leukemia. Cancers (Basel). 2020 Aug 5;12(8):2171. doi.org/10.3390/cancers12082171

2019

• • Iñaki Robles-Vera, Marta Toral, Néstor de la Visitación, Manuel Sánchez, Manuel Gómez-Guzmán, Raquel Muñoz, Francesca Algieri, Teresa Vezza, Rosario Jiménez, Julio Gálvez, Miguel Romero, Juan Miguel Redondo, Juan Duarte. Changes to the gut microbiota induced by losartan contributes to its antihypertensive effects. British Journal of Pharmacology.2020 May;177(9):2006-2023. https://doi.org/10.1111/bph.14965

• • Campos-Cuerva R, Fernandez-Munoz B, Farfan Lopez F, Pereira Arenas S, Santos-Gonzalez M, Lopez-Navas L, Alaminos M, Campos A, Muntane J, Cepeda-Franco C, Gomez-Bravo MA. Nanostructured fibrin agarose hydrogel as a novel haemostatic agent. Journal of Tissue Engineering and Regenerative Medicine, 13(4), 664–673. https://doi.org/10.1002/term.2831

• • Egea-Guerrero JJ, Carmona G, Correa E, Mata R, Arias-Santiago S, Alaminos M, Gacto P, Cuende N. Transplant of Tissue-Engineered Artificial Autologous Human Skin in Andalusia: An Example of Coordination and Institutional Collaboration. Transplantation Proceedings. Volume 51, Issue 9, November 2019, Pages 3047-3050. https://doi.org/10.1016/j.transproceed.2019.08.014

• • Bieback. K.. Fernandez-Muñoz. B.. Pati. S.. & Schäfer. R.  Gaps in the knowledge of human platelet lysate as a cell culture supplement for cell therapy: a joint publication from the AABB and the International Society for Cell & Gene Therapy. 2019 Nov;59(11):3448-3460. https://doi.org/10.1111/trf.15483

• • Garcia Delgado AB, de la Cerda B, Alba Amador J, Valdes Sanchez ML, Fernandez-Munoz B, Relimpio Lopez I, Rodriguez de la Rua E, Diez Lloret A, Calado SM, Sanchez Pernaute R, Bhattacharya SS, Diaz Corrales FJ. Subretinal Transplant of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium on Nanostructured Fibrin-Agarose. Tissue Engineering. Part A, 25(9–10),799–808. https://doi.org/10.1089/ten.TEA.2019.0007

• • Carmona-Abellan. M. Gabilondo. I. Murueta-Goyena. A. Khurana. V. Tijero. B. Luquin. M. R. Acera. M. Del Pino. R. Gardeazabal. J. Martínez-Valbuena. I. Sanchez-Pernaute. R. & Gómez-Esteban. J. C. Small fiber neuropathy and phosphorylated alpha-synuclein in the skin of E46K-SNCA mutation carriers. 2019 June 5. https://doi.org/10.1016/j.parkreldis.2019.05.038

• • Rico-Sanchez L, Garzon I, Gonzalez-Andrades M, Ruiz-Garcia A, Punzano M, Lizana-Moreno A, Munoz-Avila JI, Sanchez-Quevedo MC, Martinez-Atienza J, Lopez-Navas L, Sanchez-Pernaute R, Oruezabal RI, Medialdea S, Gonzalez-Gallardo MDC, Carmona G, Sanbonmatsu-Gamez S, Perez M, Jimenez P, Cuende N, Campos A, Alaminos M. Successful development and clinical translation of a novel anterior lamellar artificial cornea. Journal of Tissue Engineering and Regenerative Medicine. 01 August 2019. https://doi.org/10.1002/term.2951

• • Romero M, Suarez-de-Lezo J, Herrera C, Pan M, Lopez-Aguilera J, Suarez-de-Lezo JJ, Baeza-Garzon F, Hidalgo-Lesmes FJ, Fernandez-Lopez O, Martinez-Atienza J, Cebrian E, Martin-Palanco V, Jimenez-Moreno R, Gutierrez-Fernandez R, Nogueras S, Carmona MD, Ojeda S, Cuende N, Mata R. Randomised, double-blind, placebo-controlled clinical trial for evaluating the efficacy of intracoronary injection of autologous bone marrow mononuclear cells in the improvement of the ventricular function in patients with idiopathic dilated myocardiopath. BMC Cardiovascular Disorders, 19(1), 203. https://doi.org/10.1186/s12872-019-1182-4

• • Jani-Sofia Almeida, Patrícia Couceiro, Nelson López-Sejas, Vera Alves, Lenka Růžičková , Raquel Tarazona, Rafael Solana, Paulo Freitas-Tavares, Manuel Santos-Rosa, Paulo Rodrigues-Santos. NKT-Like (CD3+CD56+) Cells in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors. Front Immunol. 2019 Oct 22;10:2493. doi.org/10.3389/fimmu.2019.02493

• • Ana Navas, Juan Molina, María-Luisa Agüera, Ipek Guler, Aurora Jurado, Alberto Rodríguez-Benot, Corona Alonso, Rafael Solana. Characterization of the C1q-Binding Ability and the IgG1-4 Subclass Profile of Preformed Anti-HLA Antibodies by Solid-Phase Assays. Front Immunol. 2019 Aug 2;10:1712. doi.org/ 10.3389/fimmu.2019.01712

• • Sanchez-Correa, B., Lopez-Sejas, N., Duran, E., Labella, F., Alonso, C., Solana, R., Tarazona, R. Modulation of NK cells with checkpoint inhibitors in the context of cancer immunotherapy. Cancer Immunol Immunother. 2019 May;68(5):861-870. doi.org/10.1007/s00262-019-02336-6

• • Beatriz Sanchez-Correa, Isabel Valhondo, Fakhri Hassouneh, Nelson Lopez-Sejas, Alejandra Pera, Juan M Bergua, Maria Jose Arcos, Helena Bañas, Ignacio Casas-Avilés, Esther Durán, Corona Alonso, Rafael Solana, Raquel Tarazona. DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer Immunotherapy. Cancers (Basel). 2019 Jun 23;11(6):877. doi.org/10.3390/cancers11060877

2018

• • Cuende, N., Rasko, J. E. J., Koh, M. B. C., Dominici, M., Ikonomou, L. Cell, tissue and gene products with marketing authorization in 2018 worldwide. Cytotherapy, 20(11), 1401–1413. November 2018. https://doi.org/10.1016/j.jcyt.2018.09.010

• • Mazzini L, Ferrari D, Andjus PR, Buzanska L, Cantello R, De Marchi F, Gelati M, Giniatullin R, Glover JC, Grilli M, Kozlova EN, Maioli M, Mitrečić D, Pivoriunas A, Sanchez-Pernaute R, Sarnowska A, Vescovi AL. Advances in stem cell therapy for amyotrophic lateral sclerosis. Expert Opinion on Biological Therapy, 18(8), 865–881. https://doi.org/10.1080/14712598.2018.1503248

• • Fernández O, Izquierdo G, Fernández V, Leyva L, Reyes V, Guerrero M, León A, Arnaiz C, Navarro G, Páramo MD, De la Cuesta A, Soria B, Hmadcha A, Pozo D, Fernandez-Montesinos R, Leal M, Ochotorena I, Gálvez P, Geniz MA, Barón FJ, Mata R, Medina C, Caparrós-Escudero C, Cardesa A, Cuende N. Adipose-derived mesenchymal stem cells (AdMSC) for the treatment of secondary-progressive multiple sclerosis: A triple blinded, placebo controlled, randomized phase I/II safety and feasibility study. PLoS ONE, 13(5),e0195891. https://doi.org/10.1371/journal.pone.0195891

• • Matamoros-Angles. A. Gayosso. L. M. Richaud-Patin. Y. di Domenico. A. Vergara. C. Hervera. A. Sousa. A. Fernández-Borges. N. Consiglio. A. Gavín. R. López de Maturana. R. Ferrer. I. López de Munain. A. Raya. Á. Castilla. J. Sánchez-Pernaute. R. & Del Río. J. A. iPS Cell Cultures from a Gerstmann-Sträussler-Scheinker Patient with the Y218N PRNP Mutation Recapitulate tau Pathology. 2018 Apr;55(4):3033-3048. https://doi.org/10.1007/s12035-017-0506-6

• • Azkona. G. López de Maturana. R. Del Rio. P. Sousa. A. Vazquez. N. Zubiarrain. A. Jimenez-Blasco. D. Bolaños. J. P..Morales. B. Auburger. G. Arbelo. J. M. & Sánchez-Pernaute. R.  LRRK2 Expression Is Deregulated in Fibroblasts and Neurons from Parkinson Patients with Mutations in PINK1. Dec 14. 2018; 55(1): 506–516. https://doi.org/10.1007/s12035-016-0303-7

2017

• • González-Andrades M, Mata R, González-Gallardo MDC, Medialdea S,Arias-Santiago S, Martínez-Atienza J, Ruiz-García A, Pérez-Fajardo L, Lizana-Moreno A, Garzón I, Campos A, Alaminos M, Carmona G, Cuende N. A study protocol for a multicentre randomised clinical trial evaluating the safety and feasibility of a bioengineered human allogeneic nanostructured anterior cornea in patients with advanced corneal trophic ulcers refractory to conventional treatment. BMJ Open. 2017 Sep 24;7(9):e016487. doi: 10.1136/bmjopen-2017-016487

• • Lopez-Fabuel. I. Martin-Martin. L. Resch-Beusher. M. Azkona. G. Sanchez-Pernaute. R., Bolaños. J. P. R.  LRRK2 Mitochondrial respiratory chain disorganization in Parkinson’s disease-relevant PINK1 and DJ1 mutants. 24 March 2017. https://doi.org/10.1016/j.neuint.2017.03.023

• • Sara Cantisán, Aurora Páez-Vega, Francisco Santos, Alberto Rodríguez-Benot, Rocío Aguado, Antonio Rivero, Miguel Montejo, Julián Torre-Cisneros, Rafael Solana. Impact of age and cytomegalovirus on CD8+ T-cell compartment remodeling after solid organ transplantation: A one-year follow-up study. Exp Gerontol. 2017 Sep;95:98. doi.org/ 10.1016/j.exger.2017.04.011

• • Hassouneh, F., Lopez-Sejas, N., Campos, C., Sanchez-Correa, B., Tarazona, R., Pera, A.,Solana, R.  Effect of Cytomegalovirus (CMV) and Ageing on T-Bet and Eomes Expression on T-Cell Subsets. Int J Mol Sci. 2017 Jun 29;18(7):1391. doi.org/10.3390/ijms18071391

• • Hassouneh, F., Lopez-Sejas, N., Campos, C., Sanchez-Correa, B., Tarazona, R., Solana, R., Pera, A.  Differential Effect of Cytomegalovirus Infection with Age on the Expression of CD57, CD300a, and CD161 on T-Cell Subpopulations. Front Immunol. 2017 Jun 2;8:649. doi.org/10.3389/fimmu.2017.00649

• • Juan Molina, Ana Navas, María-Luisa Agüera, Cristian Rodelo-Haad, Corona Alonso, Alberto Rodríguez-Benot, Pedro Aljama, Rafael Solana. Impact of Preformed Donor-Specific Anti-Human Leukocyte Antigen Antibody C1q-Binding Ability on Kidney Allograft Outcome. Front Immunol. 2017 Oct 31; 8:1310. doi.org/10.3389/fimmu.2017.01310

• • Pera, A., Vasudev, A., Tan, C., Kared, H., Solana, R., Larbi, A.  CMV induces expansion of highly polyfunctional CD4+ T cell subset coexpressing CD57 and CD154. J Leukoc Biol. 2017 Feb;101(2):555-566. doi.org/10.1189/jlb.4A0316-112R

• • Beatriz Sanchez-Correa, Juan M Bergua, Alejandra Pera, Carmen Campos, Maria Jose Arcos, Helena Bañas, Esther Duran, Rafael Solana, Raquel Tarazona. In Vitro Culture with Interleukin-15 Leads to Expression of Activating Receptors and Recovery of Natural Killer Cell Function in Acute Myeloid Leukemia Patients. Front Immunol. 2017 Aug 7;8:931.doi.org/10.3389/fimmu.2017.00931

• • Raquel Tarazona, Beatriz Sanchez-Correa, Ignacio Casas-Avilés, Carmen Campos, Alejandra Pera, Sara Morgado, Nelson López-Sejas, Fakhri Hassouneh, Juan M Bergua, Maria Jose Arcos, Helena Bañas, Javier G Casado, Esther Durán, Fernando Labella, Rafael Solana. Immunosenescence: limitations of natural killer cell-based cancer immunotherapy. Cancer Immunol Immunother. 2017 Feb;66(2):233-245. doi.org/10.1007/s00262-016-1882-x

2016

• • Kim, K. H., Blasco-Morente, G., Cuende, N., Arias-Santiago, S. Mesenchymal stromal cells: properties and role in management of cutaneous diseases. Journal of the European Academy of Dermatology and Venereology, 31(3), 414–423. https://doi.org/10.1111/jdv.13934

• • Ana Fernández González, Antonio Manuel Lizana Moreno María del Mar de Pablos Ramos Antonio Ruiz García, Olga Espinosa Ibáñez, Natividad Fernández Porcel, Jorge Guerrero Calvo, Miguel Arrabal, López-Carmona, Salvador Arias-Santiago. Optimización del cultivo de queratinocitos humanos para el desarrollo de un modelo de piel artificial humana: alternativas celulares como capa alimentadora. Actual. Med. 2016; 101. doi.org/10.15568/am.2016.798.or04

• • Ana Fernández González, Antonio Manuel Lizana Moreno, Natividad Fernández Porcel, Jorge Guerrero Calvo, Antonio Ruiz García, Olga Espinosa Ibáñez, Álvaro Sierra Sánchez, Alexandra Ordoñez Luque, Salvador Arias Santiago. Estudio piloto de tolerabilidad cutánea de láminas de fibrina-agarosa en voluntarios sanos. Actual. Med. 2016; 101: (799): 171-175. doi.org/10.15568/am.2016.799.or04

• • Generación e implantación de piel artificial creada por ingeniería de tejidos fabricada en Granada: un modelo de medicina traslacional. Actual. Med. 2016; 101: (798): 65. doi.org/10.15568/am.2016.798.ed01

• • Antonio Ruiz-García, Jorge Guerrero Calvo, Natividad Fernández Porcel, Olga Espinosa Ibáñez, Antonio Manuel Lizana Moreno, Ana Fernandez Gonzalez, Salvador Arias Santiago. Validación del sistema automatizado Bact/Alert en el control microbiológico de productos celulares de Terapias Avanzadas. Actual. Med. 2016; 101: (797): 24-29. doi.org/10.15568/am.2016.797.or04

• • Izeta A, Herrera C, Mata R, Astori G, Giordano R, Hernández C, Leyva L, Arias S, Oyonarte S, Carmona G, Cuende N. Cell-based product classification procedure: What can be done differently to improve decisions on borderline products? Cytotherapy, 2016;18:809–815.(Graphical Abstract)

• • Nichols K, Janssen W, Wall D, Cuende N, Griffin D. Part 4: Interaction between unproven cellular therapies and global medicinal product approval regulatory frameworks. Cytotherapy. 2016 Jan;18(1):127-37.doi: 10.1016/j.jcyt.2015.11.003

• • Weiss DJ, Rasko JE, Cuende N, Ruiz MA, Ho HN, Nordon R, Wilton S, Dominici M, Srivastava A. Part 2: Making the «unproven» «proven». Cytotherapy. 2016 Jan;18(1):120-3.doi: 10.1016/j.jcyt.2015.11.005

• • Srivastava A, Mason C, Wagena E, Cuende N, Weiss DJ, Horwitz EM, Dominici M. Part 1: Defining unproven cellular therapies. Cytotherapy. 2016 Jan;18(1):117-9.doi: 10.1016/j.jcyt.2015.11.004

• • López de Maturana, R., Lang, V., Zubiarrain, A., Sousa, A., Vázquez, N., Gorostidi, A., Águila, J., López de Munain, A., Rodríguez, M., Sánchez-Pernaute, R. Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons J Neuroinflammation. 2016 Nov 18;13(1):295. doi.org/10.1186/s12974-016-0761-x.

• • Sara Cantisán, Aurora Páez-Vega, Pilar Pérez-Romero, Miguel Montejo, Elisa Cordero, Irene Gracia-Ahufinger, Cecilia Martín-Gandul, Naroa Maruri, Rocío Aguado, Rafael Solana, Julián Torre-Cisneros; Spanish Network for Research in Infectious Diseases (REIPI). Prevention strategies differentially modulate the impact of cytomegalovirus replication on CD8(+) T-cell differentiation in high-risk solid organ transplant patients. Antiviral Res. 2016 Aug;132:244-51. doi.org/ 10.1016/j.antiviral.2016.06.012.

• • Hassouneh, F., Campos, C., López-Sejas, N., Alonso, C., Tarazona, R., Solana, R., Pera, A.  Effect of age and latent CMV infection on CD8+ CD56+ T cells (NKT-like) frequency and functionality. Mech Ageing Dev. 2016 Sep;158:38-45. doi.org/10.1016/j.mad.2015.12.003.

• • Lopez-Sejas, N., Campos, C., Hassouneh, F., Sanchez-Correa, B., Tarazona, R., Pera, A., & Solana, R. Effect of CMV and Aging on the Differential Expression of CD300a, CD161, T-bet, and Eomes on NK Cell Subsets. Front Immunol. 2016 Nov 7;7:476. doi.org/10.3389/fimmu.2016.00476.

• • Pita-López, M. L., Pera, A., Solana, R. Adaptive Memory of Human NK-like CD8+ T-Cells to Aging, and Viral and Tumor Antigens. Front Immunol. 2016 Dec 19;7:616. doi.org/10.3389/fimmu.2016.00616.

• • Beatriz Sanchez-Correa, Carmen Campos, Alejandra Pera, Juan M Bergua, Maria Jose Arcos, Helena Bañas, Javier G Casado, Sara Morgado, Esther Duran, Rafael Solana, Raquel Tarazona. Natural killer cell immunosenescence in acute myeloid leukaemia patients: new targets for immunotherapeutic strategies?.Cancer Immunol Immunother. 2016 Apr;65(4):453-63. doi.org/ 10.1007/s00262-015-1720-6.

• • Solana, R., Tarazona, R. Challenges of vaccination in older people. Can we circumvent immunosenescence?. Maturitas. Volume 90, P1-2, August 2016. doi.org/10.1016/j.maturitas.2016.03.019.

• • Tarazona, R., Duran, E., Solana, R. Natural Killer Cell Recognition of Melanoma: New Clues for a More Effective Immunotherapy. Front Immunol. 2016 Jan 7;6:649. doi.org/10.3389/fimmu.2015.00649.

• • Cuende N, Izeta A. European Regulatory Framework for the Development of Cell-Based Medicines. Vives J, Carmona G, editores. Guide to cell therapy GxP. Quality standards in the development of cell-based medicines in non-pharmaceutical environments. USA: Academic Press, Elsevier; 2016, Pages 15-47.doi.org/10.1016/B978-0-12-803115-5.00002-4.

• • Mata RC, Cardesa A, Lora F. Good Clinical Practice in Nonprofit Institutions. . Guide to cell therapy GxP. Quality standards in the development of cell-based medicines in non-pharmaceutical environments. USA: Academic Press, Elsevier. 2016, Pages 177-229. doi.org/10.1016/B978-0-12-803115-5.00005-X.

• • Borrego, F., Larrucea, S., Solana, R., Tarazona, R. Editorial: NK Cell-Based Cancer Immunotherapy. Front Immunol. 2016 Jun 27;7:249. doi.org/10.3389/fimmu.2016.00249.

2015

• • Cuende N, Carmona G, Mata R. Introducción a las Terapias Avanzadas y a su Regulación en Europa. En: Espejo F, Rodriguez de la Rúa E, editores. Terapias avanzadas en patología de la retina. Madrid: INGENIO; 2015: 15-17.

• • Dominici M, Nichols K, Srivastava A, Weiss DJ, Eldridge P, Cuende N et al. Positioning a Scientific Community on Unproven Cellular Therapies: The 2015 International Society for Cellular Therapy Perspective. Cytotherapy, 2015;17:1663–1666. doi: 10.1016/j.jcyt.2015.10.007

• • Campos, C., López, N., Pera, A., Gordillo, J. J., Hassouneh, F., Tarazona, R., Solana, R. Expression of NKp30, NKp46 and DNAM-1 activating receptors on resting and IL-2 activated NK cells from healthy donors according to CMV-serostatus and age. Biogerontology. 2015 Oct;16(5):671-83.doi.org/10.1007/s10522-015-9581-0.

• • S. Cantisán, C. Rodelo-Haad, A Páez-Vega, A. Nieto, J M. Vaquero, A. Poyato, M Montejo, M C. Fariñas, A. Rivero, R. Solana, A. Martín-Malo, J. Torre-Cisneros. Factors related to the development of CMV-specific CD8+ T cell response in CMV-seropositive solid organ transplant candidates. Am J Transplant. 2015 Mar;15(3):715-22. doi.org/ 10.1111/ajt.13012.

• • Cantisán, S., Solana, R., Torre-Cisneros, J. Response to «Influence of Age and HLA Alleles on the CMV-Specific Cell-Mediated Immunity Among CMV-Seropositive Kidney Transplant Candidates». Am J Transplant. 2015 Sep;15(9):2527-8. doi.org/10.1111/ajt.13371.

• • El Mouraghi, I., Ouarour, A., Ghozlani, I., Collantes, E., Solana, R., El Maghraoui, A. Polymorphisms of HLA-A, -B, -Cw and DRB1 antigens in Moroccan patients with ankylosing spondylitis and a comparison of clinical features with frequencies of HLA-B*27. Tissue Antigens. 2015 Feb;85(2):108-16. doi.org/10.1111/tan.12515.

• • Sara Ferrando-Martínez, Ezequiel Ruiz-Mateos, Joseph P Casazza, Rebeca S de Pablo-Bernal, Beatriz Dominguez-Molina, M Ángeles Muñoz-Fernández, Juan Delgado, Rafael de la Rosa, Rafael Solana, Richard A Koup, Manuel Leal.. IFNγ⁻TNFα⁻IL2⁻MIP1α⁻CD107a⁺PRF1⁺ CD8 pp65-Specific T-Cell Response Is Independently Associated With Time to Death in Elderly Humans. J Gerontol A Biol Sci Med Sci. 2015 Oct;70(10):1210-8span>. doi.org/ 10.1093/gerona/glu171.

• • I Gracia-Ahufinger, S Ferrando-Martínez, M Montejo, M C Muñoz-Villanueva, S Cantisán, A Rivero, R Solana, M Leal, J Torre-Cisneros. Pre-transplant thymic function is associated with the risk of cytomegalovirus disease after solid organ transplantation. Clin Microbiol Infect. 2015 May;21(5):511.e1-7. doi.org/ 10.1016/j.cmi.2014.12.020.

• • Pera, A., Campos, C., López, N., Hassouneh, F., Alonso, C., Tarazona, R., Solana, R. Immunosenescence: Implications for response to infection and vaccination in older people. Maturitas. 2015 Sep;82(1):50-5. doi.org/10.1016/j.maturitas.2015.05.004.

• • Natalie E Riddell, Stephen J Griffiths, Laura Rivino, David C B King, Guo H Teo, Sian M Henson, Sara Cantisan, Rafael Solana, David M Kemeny, Paul A MacAry, Anis Larbi, Arne N Akbar. Multifunctional cytomegalovirus (CMV)-specific CD8(+) T cells are not restricted by telomere-related senescence in young or old adults. Immunology. 2015 Apr;144(4):549-60. doi.org/ 10.1111/imm.12409.

• • Tarazona, R., Campos, C., Pera, A., Sanchez-Correa, B., Solana, R. Flow Cytometry Analysis of NK Cell Phenotype and Function in Aging. Methods Mol Biol. 2015;1343:9-18. doi.org/10.1007/978-1-4939-2963-4_2.

2014

• • Cuende N, Boniface C, Bravery C, Forte M, Giordano R, Hildebrandt M, Izeta A, Dominici M on behalf of the Legal and Regulatory Affairs Committee: Europe of ISCT. The puzzling situation of hospital exemption for Advanced Therapy Medicinal Products in Europe and stakeholders’ concerns. Cytotherapy, 2014. Dec.16:1597-1600.doi: 10.1016/j.jcyt.2014.08.007

2013

• • Cuende N. Andalusian initiative for advanced therapies: fostering synergies. Stem Cells Transl Med. 2013 Apr;2(4):243-5.doi: 10.5966/sctm.2013-0051

• • Cuende N, Herrera C, Keating A. When the best is the enemy of the good: the case of bone-marrow mononuclear cells to treat ischemic syndromes. Haematologica. 2013 Mar;98(3):323-4. doi:10.3324/haematol.2013.086231

2012

• • Cuende N, Rico L, Herrera C. Bone marrow mononuclear cells for the treatment of ischemic syndromes: medicinal product or cell transplantation?. Stem Cells Translational Medicine. 2012;1:403–408. doi:10.5966/sctm.2011-0064

  • Álvarez Márquez A, Pérez Valdivia MA, Ángel M, Castro de la Nuez P, Díaz Aunión C, Huet Ruiz-Matas J, Cuende Melero N, Alonso Gil M. Biovigilancia de órganos, células y tejidos en Andalucía. Comisión de Trasplantes del Hospital Virgen del Rocío. Actualizaciones en Trasplantes 2012. Sevilla: Hospitales Universitarios Virgen del Rocío, 2012: 96-102.

2011

• • Cuende N, Carmona G, Cardesa A, Oruezabal I, Rico L, Mata R.  Regulatory complexities in the clinical translation of stem cells: the experience of the Andalusian initiative for advanced therapies.. Regenerative Medicine. Volume 6 Issue 6. Supplement 2-57.

2010

• • Cuende N, Izeta A. Clinical translation of stem cell therapies: a bridgeable gap. Cell Stem Cell. 2010;6(6):508-12.doi: 10.1016/j.stem.2010.05.005

• • Cuende N, Zugaza JL. The Andalusian Iniative for Advanced Therapies. European BioPharmaceutical Review. Samedan Ltd. Editores. April issue, 2010.

• • Cuende N. Iniciativa Andaluza en Terapias Avanzadas: Desarrollo y Perspectivas. Moreno Muñoz M, coordinador. Perspectivas en la investigación con células troncales. Aspectos científicos, éticos, sociales y legales. Granada: Editorial Comares; Biblioteca de derecho y ciencias de la vida; 2010:253-265.

• • Estrategia y Plan de Actuación 2010-2015 de la Iniciativa Andaluza en terapias Avanzadas. Depósito legal Se-2377/2010.